Epidemiology of patients in England and Wales with autosomal dominant polycystic kidney disease and end-stage renal failure
Background Autosomal dominant polycystic kidney disease (ADPKD) is the leading genetic cause of end-stage renal failure (ESRF). The epidemiology of the incident ADPKD patient cohort requiring renal replacement therapy (RRT) in England and Wales has not been described.
Methods We used a retrospective cohort design. Incident adult patients commencing RRT between 1 January 2000 and 31 December 2011 in England and Wales were identified from the UK Renal Registry. Patients were stratified into three groups based on primary renal diagnosis (PRD): (i) ADPKD, (ii) diabetes as PRD, (iii) individuals with another PRD (‘other’). Baseline demographics, comorbidity, care-related measures and outcomes including patient survival are described.
Results A total of 52 608 individuals started RRT during the study period, 3598 (6.8%) had ADPKD, 12 137 (23.1%) diabetes as PRD and 36 873 had another PRD diagnosis. The median age of commencing RRT was 55 years in the ADPKD group compared with 62 and 66 years in those with diabetes or ‘other’ PRD, respectively. The median age of starting RRT did not…